People ask me almost daily what the side effects of roaccutane. I'll do a video at some point explaining it all... However, the biggest side effect I have is EXTREMELY dry lips. My lips crack and are very painful every day. Roaccutane is meant to dry your skin, and it dries up your lips a hell of a lot. It also dries the skin in your nose... it's pretty uncomfortable. However, whilst tristan likes to mock me for having loads of lip balm on my lips, if I don't, my lips will crack and bleed like this. Therefore, if you're thinking about roaccutane, make sure you find the best lip balms you can first!